![]() ![]() This is in contrast to Str–GP synapses which display facilitation under both conditions. (iii) In response to 20 and 50 Hz train stimulation, GP–GP synapses are weakly facilitatory in 1 m m external calcium and depressant in 2.4 m m calcium. (ii) Compared to GP–GP synapses Str–GP synapses have a greater paired-pulse ratio, indicative of a lower probability of release. ![]() We found (i) IPSC kinetics are consistent with local collaterals innervating the soma and proximal dendrites of GP neurons whereas striatal inputs innervate more distal regions. The basic synaptic characteristics of GP–GP and Str–GP GABAergic synapses were studied using whole-cell recordings with paired-pulse and train stimulation protocols and variance–mean (VM) analysis. Here we provide electrophysiological evidence for functional differences between these two inhibitory inputs. Driven by intrinsic mechanisms and excitatory glutamatergic inputs from the subthalamic nucleus, GP neurons receive GABAergic inhibitory input from the striatum (Str–GP) and from local collaterals of neighbouring pallidal neurons (GP–GP). As a central integrator of basal ganglia function, the external segment of the globus pallidus (GP) plays a critical role in the control of voluntary movement. ![]()
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